Research Labs: Cecilia Cheng-Mayer, PhD.
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Cecilia Cheng-Mayer, PhD.
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Name: Cecilia Cheng-Mayer

Address:

Professor/Staff Investigator
Aaron Diamond AIDS Research Center
The Rockefeller University
455 First Avenue
New York, NY 10016

Education:

1968-1972 University of California, Berkeley, A.B.
1972-1978 Columbia University, New York, Ph.D.
1978-1981 Sloan-Kettering Institute for Cancer Research Post-Doc

Professional Experience

1973-1974

Teaching Assistant in Medical Microbiology, Columbia University, New York

1975

Teaching Assistant in Infectious Disease, Columbia University, New York

1981-1982

Associate Researcher, Sloan-Kettering Institute for Cancer Research

1982-1985

Research Assistant, University of Miami School of Medicine, Miami

1985-1986

Research Scholar, University of California, San Francisco

1986-1989

Assistant Research Virologist, Cancer Research Institute UCSF School of Medicine

1990-1994

Associate Research Virologist, Cancer Research Institute UCSF School of Medicine

1994-present

Staff Investigator, Aaron Diamond AIDS Research Center, New York

1994-2002

Associate Professor, The Rockefeller University, New York

2003-present

Aaron Diamond Professor at the Rockefeller University, New York

Publications (selected):

  1. Cheng-Mayer C, Seto D, Tateno M and Levy JA. 1988. Biologic features of HIV that correlate with virulence in the host.  Science 240: 80-82.

  2. Shioda T, Levy JA and Cheng-Mayer C. 1991. Macrophage and T‑cell line tropisms of HIV‑1 are determined by specific regions of the envelope gp120.  Nature 349: 167-169.

  3. Shioda T, Levy JA, and Cheng-Mayer C. 1992. Small amino acid changes in the V3 hypervariable region of gp120 can affect the T-cell and macrophage tropism of human immunodeficiency virus type 1. Proc Natl Acad Sci USA, 89:9434-9438.

  4. Stamatatos L and Cheng-Mayer C. 1993. Evidence that the structural conformation of envelope gp120 affects HIV-1 infectivity, host range and syncytium-forming ability. J Virol. 67:5635-5639.

  5. Koito A, Harrowe G, Levy JA and Cheng-Mayer C. 1994. Functional role of the V1/V2 domain of human immunodeficiency virus type 1 envelope glycoprotein gp120 in infection of primary macrophages and soluble CD4 neutralization. J Virol, 68:2253-2259.

  6. Allan JS, Ray R, Broussard S, Whitehead E, Hubbard G, Butler T, Brasky K, Luciw P, Cheng-Mayer C, Levy JA, Steimer K, Li J, Sodroski J and Garcia-Moll, M. 1995. Infection of baboons with simian/human immunodeficiency viruses. JAIDS 9:429-441.

  7. Luciw PA, Pratt-Lowe E, Shaw KES, Levy JA and Cheng-Mayer C. 1995. Persistent infection of rhesus macaques with T-cell line-tropic and macrophage-tropic clones of simian/human immunodeficiency viruses (SHIV). Proc Natl Acad Sci92:7490-7494.

  8. Stamatatos L and Cheng-Mayer C. 1995. Structural modulations of the envelope gp120 glycoprotein of HIV-1 upon oligomerization and differential V3 loop-epitope exposure for isolates displaying distinct tropism upon virion-soluble receptor binding. J Virol, 69:6191-6198.

  9. Trkola A, Dragic T, Arthos J, Binley JM, Olson WC, Allaway GP, Cheng-Mayer C, Robinson J, Maddon PJ and Moore JP 1996. Interference with HIV-1 gp120 binding to the chemokine receptor CCR-5 by neutralizing antibodies. Nature 384:184-187.

  10. Cheng-Mayer C, Liu R, Landau NR and Stamatatos L. 1997. Macrophage tropism of HIV-1 and utilization of the CC-CKR5 coreceptor. J Virol, 71:1657-1661.

  11. Harouse JM, Tan RCH, Gettie A, Dailey P, Marx PA, Luciw PA and Cheng-Mayer C.  1998. Mucosal transmission of pathogenic CXCR4-utilizing SHIVSF33A variants in rhesus macaques.  Virol, 248:95-107.

  12. Stamatatos L and Cheng-Mayer C. 1998. An envelope modification that renders a primary, neutralization resistant, clade B HIV-1 isolate highly susceptible to neutralization by sera from other clades.  J Virol, 72:7840-7845.

  13. Luciw PA, Mandell C, Himathongkham S, Li J, Low TA, Schmidt KA, Shaw KES and Cheng-Mayer C. 1999. Fatal immunopathogenesis by SIV/HIV-1 (SHIV) containing the HIV-1SF33 env gene in juvenile and newborn rhesus macaques.  Virol, 263:112-127.

  14. Cheng-Mayer C, Brown A, Harouse J, Luciw PA and Mayer AJ. 1999. Selection for neutralization resistance of the SHIVSF33A variant in vivo by virtue of sequence changes in the extracellular envelope glycoprotein that modify N-linked glycosylation.  J Virol, 73:5294-5300.

  15. Harouse JM, Gettie A, Tan RCH, Blanchard J and Cheng-Mayer C. 1999. Distinct pathogenic sequela in rhesus macaques infected with CCR5 or CXCR4 utilizing SHIVs.  Science, 284:816-819.

  16. Brown A, Wang X, Sawai E and Cheng-Mayer C. 1999. Activation of the PAK-related kinase by HIV-1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX/p95 complex. J Virol, 73:9899-9907.

  17. Chakrabarti LA, Lewin SR, Zhang L, Gettie A, Luckay A, Martin LN, Skulsky E, Ho DD,Cheng-Mayer C, Marx PA 2000. Normal T-cell turnover in Sooty Mangabeys harboring active simian immunodeficiency virus infection. J Virol, 74: 1209-1223.

  18. Chakrabarti L, Lewin SR, Zhang L, Gettie A, Luckay A, Martin LN, Skulsky E, Ho DD, Cheng-Mayer C and Marx PA. 2000. Age-dependent changes in T cell homeostasis and SIV load in sooty mangabeys. J Med Primatol, 29:158-165.

  19. Harouse JM, Gettie A, Eshetu T, Tan RCH, Bohm R, Blanchard J, Baskin G and Cheng-Mayer C. 2001. Mucosal transmission and induction of simian AIDS by CCR5-specific SHIV SF162P. J Virol, 75:1990-1995.

  20. Malenbaum S, Yang D and Cheng-Mayer C. 2001. Evidence for similar recognition of the conserved neutralization epitopes of HIV-1 gp120 in humans and macaques. J Virol, 75:9287-9296.

  21. Parren PWHI, Marx PA, Hessell AJ, Luckay A, Harouse J, Cheng-Mayer C, Moore JP and Burton DR 2001. Antibody protects against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro. J Virol, 75:8340-8347.

  22. Chakrabarti L, Ivanovic T and Cheng-Mayer C. 2002. Properties of the surface envelope glycoprotein associated with virulence of Simian-Human Immunodeficiency virus SHIVSF33A molecular clones. J Virol, 76:1588-1599.

  23. Lue,J, Hsu M, Yang D, Marx P, Chen Z and Cheng-Mayer C. 2002. Addition of a single gp120 glycan confers increased binding to DC-SIGN and neutralization escape to HIV-1. J Virol, 76:10299-10306.

  24. Hsu M, Harouse JM, Gettie A, Buckner C, Blanchard J and Cheng-Mayer C. 2003. Increased mucosal transmission but not enhanced pathogenicity of the CCR5-tropic, SAIDS-inducing SHIVSF162P3 maps to envelope gp120. J Virol, 77:989-998.

  25. Chakrabarti LA, Metzner KJ, Ivanovic T, Cheng H, Louis-Virelizier J, Connor RI and Cheng-Mayer C. 2003. A multiply deleted form of Nef selected during pathogenic reversion of SIVmac239-Dnef increases viral replication. J Virol, 77:1588-1599.

  26. Hsu M, Zhang J, Flint M, Logvinoff C, Cheng-Mayer C, Rice CM and McKeating J. 2003. Hepatitis C virus glycoproteins mediate pH-dependent fusion and cell entry of pseudotyped retroviral particles. Proc Natl Acad Sci USA, 100:7271-7276.

  27. Harouse JM, Buckner C, Gettie A, Fuller R, Bohm R, Blanchard J and Cheng-Mayer C. 2003. CD8+ T cell-mediated CXCR4-SHIV suppression in dually-infected rhesus macaques. Proc Natl Acad Sci USA, 100:10977-10982.

  28. Reyes RA, Canfield DR, Esser U, Adamson LA, Cheng-Mayer C, Gardner M, Harouse JM and Luciw PA.  2004. Induction of simian AIDS in neonatal rhesus macaques infected with CCR5 and CXCR4 utilizing SHIV is associated with distinct lesions of the thymus. J Virol, 78:2121-2130.

  29. Balfe P, Shapiro S, Hsu M, Buckner C, Harouse J and Cheng-Mayer C. 2004. Expansion of quasispecies diversity but no evidence for adaptive evolution of SHIV during rapid serial transfers between seronegative macaques. Virol, 318:267- 279.

  30. Brown A, Moghaddam S, Kawano T and Cheng-Mayer C. 2004. Multiple human immunodeficiency virus type 1 Nef functions contribute to efficient replication in primary human macrophages. J Gen Virol,  85:1463-1469.

  31. Saunders CJ, McCaffrey RA, Zharkikh I, Kraft Z, Malenbaum SE, Burke B, Cheng-Mayer C and Stamatatos L. 2005. The V1, V2, and V3 regions of the human immunodeficiency virus type 1 envelope differentially affect the viral phenotype in an isolate-dependent manner. J Virol, 79:9069-9080.

  32. Cheng H, Cenciarelli C, Nelkin G, Tsan R, Fan C, Cheng-Mayer C and Fidler IJ. 2005. Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth. Mol Cell Biol, 25:44-59.

  33. Brown A, Gartner S, Kawano T, Benoit N and Cheng-Mayer C. 2005. HLA-A2 down-regulation on primary human macrophages infected with an M-tropic EGFP-tagged HIV-1 reporter virus. J Leukoc Biol, 78:675-685.

  34. Ratterree M, Gettie A, Williams V, Malenbaum S, Neurath AR, Cheng-Mayer C and Blanchard J. 2005. Safety and distribution of cellulose acetate 1,2-benzenedicarboxylate (CAP), a candidate anti-HIV microbicide in rhesus macaques. AIDS, 19:1595-1599.

  35. Hsu M, Ho SH, Balfe P, Gettie A, Harouse J, Blanchard J and Cheng-Mayer C. 2005. A CCR5-tropic simian-HIV molecular clone capable of inducing AIDS in rhesus macaques. J Acquir Immune Defic Syndr 40:383-387.

  36. Ho SH, Shek L, Gettie A, Blanchard J and Cheng-Mayer C. 2005. V3 loop-determined coreceptor preference dictates the dynamics of CD4+-T-cell loss in simian-human immunodeficiency virus-infected macaques. J Virol, 79:12296-12303.

  37. Boadi T, Schneider E, Chung S, Tsai L, Gettie A, Ratterree M, Blanchard J, Neurath AR and Cheng-Mayer C. 2005. Cellulose acetate 1,2-benzenedicarboxylate protects against challenge with pathogenic X4 and R5 simian/human immunodeficiency virus. AIDS 19:1587-1594.

  38. Trunova N, Tsai L, Tung S, Schneider E, Harouse J, Gettie A, Simon V, Blanchard J and Cheng-Mayer C. 2006. Progestin-based contraceptive suppresses cellular immune responses in SHIV-infected rhesus macaques. Virology, 352:169-177.

  39. Ho SH, Martin F, Higginbottom A, Partridge LJ, Parthasarathy V, Moseley GW, Lopez P, Cheng-Mayer C and Monk PN. 2006. Recombinant extracellular domains of tetraspanin proteins are potent inhibitors of the infection of macrophages by human immunodeficiency virus type 1. J Virol 80:6487-96.

  40. Tsai L, Trunova N, Gettie A, Mohri H, Bohm R, Saifuddin M, Cheng-Mayer C. 2007. Efficient repeated low-dose intravaginal infection with X4 and R5 SHIVs in rhesus macaque: Implications for HIV-1 transmissions in humans. Virology, in press.

  41. Tasca S, Tsai L, Trunova N, Gettie A, Saifuddin M, Bohm R, Chakrabarti L, Cheng-Mayer C. 2007. Induction of potent local cellular immunity with low dose X4 SHIVSF33A vaginal exposure: correlations with protection from re-exposure. Submitted.

  42. Ho SH, Shek L, Li A, Gettie A, Blanchard J, Boden D, Cheng-Mayer C. 2007. Coreceptor switch in a macaque infected with CCR5 (R5)-tropic simian-human immunodeficiency virus. Manuscript in preparation
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