Research Labs: David D. Ho, M.D.
Selected Publications (from 350)

Scientific Overview Non-Scientific Summary David D. Ho, M.D.    CV    Biography    Personnel    Publications Return to Research Programs

1. Zhu T, Mo H, Wang N, Nam DS, Cao Y, Koup R, Ho DD. Genotypic and phenotypic characterization of HIV-1 in patients with primary infection. Science 1993; 261:1179-81. [view]
   
   
2. Cao Y, Qin L, Zhang GL, Safrit J, Ho DD. Virologic and immunologic characterization of long-term survivors of HIV-1 infections. N. Engl. J. Med. 1995; 332:201-8. [view]
   
   
3. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virion and CD4 lymphocytes in HIV-1 infection. Nature 1995; 373:123-6.
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4. Markowitz M, Saag M, Powderly W, Hurley AM, Hsu A, Valdes JM, Henry D, Sattler F, La Marca A, Leonard JM, Ho DD. A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection. N. Engl. J. Med. 1995; 333:1534-9. [view]
   
   
5. Ho DD. Time to hit HIV, early and hard. N. Engl. J. Med. 1995; 333:450-1. [view]
   
   
6. Spira AI, Marx PA, Patterson BK, Mahoney J, Koup RA, Wolinsky SM, Ho DD. Cellular targets of infection and route of viral dissemination following intravaginal inoculation of SIV into rhesus macaques. J. Exp. Med. 1996; 183:215-25. [view]
   
   
7. Perelson AS, Neumann AU, Markowitz M, Leonard J, Ho DD. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 1996; 271:1582-6. [view]
   
   
8. Ho DD. Viral counts count in HIV infection. Science 1996; 272:1124-5. [view]
   
   
9. Huang Y, Paxton WA, Wolinsky SM, Neumann AU, Zhang L, He T, Kang S, Ceradini D, Jin Z, Yazdanbakhsh K, Kunstman K, Erickson D, Dragon E, Landau N, Phair J, Ho DD, Koup RA. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nature Med. 1996; 2:1240-3. [view]
   
   
10. Perelson AS, Essunger P, Cao Y, Vesanen M, Hurley A, Saksela K, Markowitz M, Ho DD. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 1997; 387:188-91. [view]
    
    
11. Zhu T, Korber BT, Nahmias AJ, Hooper E, Sharp PM, Ho DD. An African HIV-1 sequence from 1959 and implications for the origin of the epidemic. Nature 1998; 391:594-7. [view]
    
    
12. Mohri H, Bonhoeffer S, Monard S, Perelson AS, Ho DD. Rapid turnover of T lymphocytes in SIV-infected rhesus macaques. Science 1998; 279:1223-7. [view]
    
    
13. Ho DD. Toward HIV eradication or remission: the tacks ahead. Science 1998; 280:1866-7. [view]
    
    
14. Kostrikis LG, Huang Y, Moore JP, Wolinsky SM, Zhang L, Guo Y, Deutsch L, Phair J, Neumann AU, Ho DD. A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nature Med. 1998; 4:350-3. [view]
    
    
15. Zhang L, Ramratnam B, Tenner-Racz, He Y, Vesanen M, Lewin S, Talal A, Racz P, Perelson AS, Korber BT, Markowitz M, Ho DD. Quantifying residual HIV-1 replication in patients receiving effective combination antiretroviral therapy. N. Engl. J. Med. 1999; 340:1605-13. [view]
    
    
16. Jin X, Bauer DE, Tuttleton SE, Lewin S, Gettie A, Kostrikis L, Blanchard J, Irwin CE, Safrit JT, Zhang L, Ho DD. Dramatic rise in plasma viremia after CD8+ T-cell depletion in simian immunodeficiency virus-infected macaques. J. Exp. Med. 1999; 189:991-8. [view]
    
    
17. Ramratnam B, Bonhoeffer S, Binley J, Hurley A, Zhang L, Mittler, Markowitz M, Moore JP, Perelson AS, Ho DD. Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet 1999; 354:1782-5. [view]
    
    
18. Zhang L, Lewin S, Markowitz M, Lin H-H, Skulsky E, Karanicolas R, He Y, Jin X, Tuttleton S, Vesanen M, Spiegel H, Kost R, J. van Lunzen, H-J. Stellbrink, Wolinsky S, Borkowsky W, Palumbo P, Kostrikis LG, Ho DD. Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy. J. Exp. Med. 1999; 190:725-32. [view]
    
    
19. Ramratnam B, Mittler JE, Zhang L, Boden D, Hurley A, Fang F, Macken CA, Perelson AS, Markowitz M, Ho DD. The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged antiretroviral therapy. Nature Med. 2000; 6:82-5. [view]
    
    
20. Zhang L, Chung C, Hu B-S, He T, Guo Y, Kim AJ, Skulsky E, Jin X, Hurley A, Ramratnam B, Markowitz M, Ho DD. Genetic characterization of rebounding HIV-1 after cessation of highly active antiretroviral therapy. J. Clin. Investig. 2000; 106:839-45. [view]
    
    
21. Mohri H, Perelson AS, Tung K, Ribeiro R, Ramratnam B, Markowitz M, Kost R, Hurley A, Weinberger L, Cesar D, Hellerstein MK, Ho DD. Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy. J. Exp. Med. 2001; 194:1277-87. [view]
    
    
22. Ho DD and Huang Y. The HIV-1 vaccine race. Cell. 2002; 110:135-8. [view]
    
    
23. Linqi Zhang, Wenjie Yu, Tian He, Jian Yu, Rebecca E. Caffrey, Enrique A. Dalmasso, Siyu Fu, Thang Pham, Jianfeng Mei, Jaclyn J. Ho, Wenyong Zhang, Peter Lopez, David D. Ho. Contribution of Human {alpha}-Defensin-1, -2 and -3 to the Anti-HIV-1 Activity of CD8 Antiviral Factor. Science. 2002; 298:995-1000. [view]
    
    
24. Markowitz M, Louie M, Hurley A, Sun E, Di Mascio M, Perelson AS, Ho DD. A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo. J Virol. 2003 Apr;77(8):5037-8. [view]
    
    
25. Simon V, Ho DD. HIV-1 dynamics in vivo: implications for therapy. Nat Rev Microbiol. 2003 Dec;1(3):181-90. [view]
    
    
26. Arron ST, Ribeiro RM, Gettie A, Bohm R, Blanchard J, Yu J, Perelson AS, Ho DD, Zhang L. Impact of thymectomy on the peripheral T cell pool in rhesus macaques before and after infection with simian immunodeficiency virus. Eur J Immunol. 2005 Jan;35(1):46-55. [view]
    
    
27. Ho DD. A Shot in the Arm for AIDS Vaccine Research. PLoS Med. 2005 Jan 18;2(2):e36 [view]
    
    
28. Chen Z, Zhang L, Qin C, Ba L, Yi CE, Zhang F, Wei Q, He T, Yu W, Yu J, Gao H, Tu X, Gettie A, Farzan M, Yuen KY, Ho DD. Recombinant modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region. J Virol. 2005 Mar;79(5):2678-88. [view]
    
    
29. Markowitz M, Mohri H, Mehandru S, Shet A, Berry L, Kalyanaraman R, Kim A, Chung C, Jean-Pierre P, Horowitz A, La Mar M, Wrin T, Parkin N, Poles M, Petropoulos C, Mullen M, Boden D, Ho DD. Infection with multidrug resistant, dual-tropic HIV-1 and rapid progression to AIDS: a case report. Lancet. 2005 Mar 16;365(9464):1031-8. [view]
    
    
30. Kinjo Y, Wu D, Kim G, Xing GW, Poles MA, Ho DD, Tsuji M, Kawahara K, Wong CH, Kronenberg M. Recognition of bacterial glycosphingolipids by natural killer T cells. Nature. 2005 Mar 24;434(7032):520-5. [view]