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Research Labs: Yaoxing Huang, PhD.
Curriculum Vitae
Name: Yaoxing Huang
Address:
Aaron Diamond AIDS Research Center
The Rockefeller University
455 First Avenue
New York, NY 10016
Telephone: 212-448-5000
Telefax: (212) 725-1126
Education:
| 1988 |
Public health/medicine, Shanghai Medical University, China |
| 1994 |
Microbiology, New York University, NY |
| 1997 |
Virology, New York University, NY |
Professional Experience:
| 1997-2001 |
Postdoctoral Research Fellow, Aaron Diamond AIDS Research Center |
| 2001-2003 |
Research Scientist, Aaron Diamond AIDS Research Center |
| 2003-Present |
Staff Investigator, Aaron Diamond AIDS Research Center, Assistant Professor, The Rockefeller University
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Publications:
- Moore JP, JA McKeating, Y Huang, A Ashkenazi and Ho DD. 1992. Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates. J Virol. 66: 235-43.
- Huang Y, L Zhang and Ho DD. 1995. Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection. J Virol. 69: 93-100.
- Huang Y, L Zhang and Ho DD. 1995. Biological characterization of nef in long-term survivors of human immunodeficiency virus type 1 infection. J Virol. 69: 8142-6.
- Dragic T, V Litwin, GP Allaway, SR Martin, Y Huang, KA Nagashima, C Cayanan, PL Maddon, RA Koup, JP Moore and Paxton WA. 1996. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR5. Nature. 381: 667-73.
- Zhang L, Y Huang, T He, Y Cao and Ho DD. 1996. HIV-1 subtype and second-receptor use. Nature 383: 768.
- Huang Y, WA Paxton, SM Wolinsky, AU Neumann, L Zhang, T He, S Kang, D Ceradini, X Jin, K Yazdanbakhsh, K Kunstman, D Erickson, E Dragon, NR Landau, J Phair, DD Ho and Koup RA. 1996. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nature Med. 2: 1240-3.
- Zhang L, YHuang, H Yuan, S Tuttleton and Ho DD. 1997. Genetic characterization of vif, vpr, and vpu sequences from long-term survivors of human immunodeficiency virus type 1 infection. Virology 228: 340-9.
- Zhang L, YHuang, H Yuan, BK Chen, J Ip and Ho DD. 1997. Identification of replication-competent pathogenic human immunodeficiency virus type 1 with a duplication in the TCF-1 alpha region but lacking NF-kappaB binding sites. J Virol. 71: 1651-6.
- Zhang L, YHuang, BK Chen, J Ip and Ho DD. 1997. Genotypic and phenotypic characterization of long terminal repeat sequences from long-term survivors of human immunodeficiency virus type 1 infection. J Virol. 71: 5608-13.
- Zhang L, CD Carruthers, T He, YHuang, Y Cao, G Wang, B Hahn and Ho DD. 1997. HIV type 1 subtypes, coreceptor usage, and CCR5 polymorphism. AIDS Res Human Retroviruses 13: 1357-65.
- Huang Y, L Zhang and Ho DD. 1998. Characterization of gag, and pol sequences from long-term survivors of human immunodeficiency virus type 1 infection. Virology 240: 36-49.
- Kostrikis LG, YHuang, JP Moore, SM Wolinsky, L Zhang, Y Guo, L Deutsch, J Phair, AU Neumann and Ho DD. 1998. A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nature Med. 4: 350-353.
- Zhang L, T He, YHuang, Z Chen, Y Guo, S Wu, KJ Kunstman, RC Brown, JP Phair, AU Neumann, DD Ho and Wolinsky SM. 1998. Chemokine coreceptor usage by diverse primary isolates of human immunodeficiency virus type 1. J Virol. 72: 9307-12.
- Binley JM, X Jin, YHuang, L Zhang, Y Cao, DD Ho and Moore JP. 1998. Persistent antibody responses but declining cytotoxic T-lymphocyte responses to multiple human immunodeficiency virus type 1 antigens in a long-term nonprogressing individual with a defective p17 proviral sequence and no detectable viral RNA expression. J Virol. 72: 3472-4.
- Kostrikis LG, AU Neumann, B Thomson, BT Korber, P McHardy, R Karanicolas, L Deutsch, Y Huang, JF Lew, K McIntosh, H Pollack, W Borkowsky, HM Spiegel, P Palumbo, J Oleske, A Bardeguez, K Luzuriaga, J Sullivan, SM Wolinsky, RA Koup, DD Ho and Moore JP. 1999. A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to African American infants. J Virol. 73: 10264-71.
- Jin X, C Robert, D Nixon, J Safrit, L Zhang, YHuang, B Bhardwaj, A DeGroot and Koup RA. 2001. Identification of subdominant cytotoxic T lymphocyte epitopes encoded by autologous HIV type 1 sequences, using dendritic cell stimulation and computer-driven algorithm. AIDS Res Hum Retroviruses, 16: 67-76.
- Chen Z, YHuang, X Zhao, E Skulsky, S Lewin, D Lin, J Ip, A Gettie and Ho DD. 2000. Enhanced infectivity of an R5-tropic SHIVCHN19 carrying HIV-1 subtype C envelope after passages in pig-tailed macaques (Macaca nemestrina). J Virol. 74: 6501-10.
- Foster JL, RP Molina, T Luo, VK Arora, YHuang, DD Ho and Garcia JV. 2001. Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates. J Virol. 75: 1672-80.
- Chen Z, X Zhao, YHuang, A Gettie, L Ba, J Blanchard and Ho DD. 2002. CD4+ lymphocytopenia in acute infection of Asian macaques by a vaginally transmissible subtype-C, CCR5-tropic Simian/Human Immunodeficiency Virus (SHIV). J Acquir. Immune. Defic. Syndr. 30: 133-45.
- Ho DD and HuangY. 2002. The HIV-1 Vaccine Race. Cell (review). 110: 135-8.
- 21. Simon V, Zennou V, Murray D, Huang Y, Ho DD and Bieniasz PD. 2005. Natural variation in Vif: differential impact on APOBEC3G/3F and a potential role in HIV-1 diversification. PLoS Pathogens. 1: 1-9.
- Gardiner D, Huang Y, Basu S, Leung L, Song Y, Chen Z and Ho DD. 2006. Multiple-site DNA vaccination enhances immune responses in mice. Vaccine 24: 287-292.
- Trumpfheller C, Finke JS, Lopez CB, Moran TM, Moltedo B, Soares H, Huang Y, Schlesinger SJ, Park CG, Nussenzweig MC, Granelli-Piperno A and Steinman RM. 2006. Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. J Exp Med 203:607-17.
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