Research Labs: Moriya Tsuji, M.D., Ph.D.
Selected Publications

Scientific Overview
Non-Scientific Summary

Moriya Tsuji, M.D., Ph.D.
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   Publications

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  1. Machado F, Desruisseau MS, Nagajyoshi, Kennan RP, Hetherington HP, Wittner M, Weiss LM, Lee SC, Scherer PE, Tsuji M, Tanowitz HB. 2006.  Endothelin in a Murine Model of Cerebral Malaria.  Exp. Biol. Med.  231: 1176-81. [view]
  2. Chen G, Chien M, Tsuji M, Franck RW. 2006.  E and Z αC-Galactosylceramides via Julia-Lythgoe-Kocienski Chemistry: A Test of the Receptor Binding Model for Glycolipid Immunostimulants.  Chem. Bio. Chem.  7: 1017-22. [view]
  3. Fujio M, Wu D, Garcia-Navarro R, Ho D.D, Tsuji M, Wong C-H. 2006. Structure-Based Discovery of Glycolipids for CD1d-mediated NKT cell activation: Tuning the Adjuvant versus Immunosuppression Activity.  J. Am. Chem. Soc.  128: 9022-3. [view]
  4. Tsuji M. 2006.  Glycolipids and phospholipids as natural CD1d-binding NKT cell ligands.  Cell. Mol. Life Sci.  63:1889-98. Review.
  5. Fujii S, Shimizu K, Hemmi H, Fukui M, Bonito AJ, Franck RW, Tsuji M, Steinman RM. 2006. Gycolipid α-C-GalCer is a distinct inducer of dendritic cell maturation and both innate and adaptive T cell immunity in mice.  Proc.Natl.Acad.Sci. USA.  103:11252-7. [view]
  6. Kinjo Y, Tupin E, Wu D, Fujio M, Garcia-Navarro R, Benhnia M, Zajonc DM, Ben-Menachem G, Ainge GD, Painter GF, Khurana A, Hoebe K, Behar SM, Beutler B, Wilson IA, Tsuji M, Sellati TJ, Wong C-H, Kronenberg M. 2006. NKT cells recognize diacylglycerol antigens from pathogenic bacteria.  Nat. Immunol. 7: 978-86. [view]
  7. Franck RW, Tsuji M. 2006. α-C-Galactosylceramides: Synthesis and Immunology.  Acc. Chem. Res.  39: 692-701. [view]
  8. Vasan S, Poles MA, Horowitz A, Siladji EE, Markowitz M, Tsuji M.  2006. Percentage and function of NKT cells, a potential anti-HIV effector cell, are preserved by beginning HAART during acute and early HIV-1 Infection.  Int. Immunol. Submitted.
  9. Charalambous A, Spisek R, Chang, DH, Oks M, Matthews P, Wong C-H, Tsuji M, Dhodapkar MV, Steinman RM. 2006.  Glycolipid 3-O-sulfo-α-galactosylceramide (97A) as a novel anti-tumor natural killer T (NKT) ligand leading to greater induction of IFNγ and IL-12 than α-galactosylceramide.  Clin. Cancer Res.  Submitted.
  10. Coppieters K, Van Beneden K, Jacques P, Dewint P, Vervloet A, Vander Cruyssen B, Van Calenbergh S, Chen G, Franck R.W, Heremans H, De Clercq B, Verbruggen G, Deforce D, Matthys P, Tsuji M, Rottiers P, Elewaut D.  2006. Long-term IFN-g Dependent Efficacy of Activated Va14i Natural Killer T cells in the Prevention of Collagen-Induced Arthritis.  J. Immunol. Submitted.
  11. Ophorst OJAE, Radosevic K, Havenga MJE, Pau MG, Holterman L, Berkhout B, Goudsmit J, Tsuji M.  2006.  Recombinant human adenovirus serotype 35-based malaria vaccine: Immunogenicity and protection against Plasmodium yoelii in mice.  Infect. Immun. 74: 313-20. [view]
  12. Kennan RP, Machado FS, Lee SC, Desruisseaux MS, Wittner M, Tsuji M, Tanowitz, HB.  2005.  Reduced cerebral blood flow and N-acetyl aspartate in a murine model of cerebral malaria.  Parasitol Res  96: 302 - 7. [view]
  13. Kinjo Y, Wu D, Kim G, Xing G-w, Poles MA, Ho DD, Tsuji M, Kawahara K, Wong C-H, Kronenberg M.  2005.  Recognition of bacterial glycosphingolipids by natural killer T cells.  Nature  434: 520 - 5. [view]
  14. Xing GW, Wu D, Poles MA, Horowitz A, Tsuji M, Ho DD, Wong CH. 2005  Synthesis and human NKT cell stimulating properties of 3-O-sulfo-alpha/beta-galactosylceramides. Bioorg Med Chem. 13:2907-16. [view]
  15. Wu D, Xing GW, Poles MA, Horowitz A, Kinjo Y, Sullivan B, Bodmer-Narkevitch V, Plettenburg O, Kronenberg M, Tsuji M, Ho DD, Wong C-H.  2005.  Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells.  Proc Natl Acad Sci USA.  102: 1351 - 6. [view]
  16. Schmieg J, Yang G, Franck RW, Van Rooijen N, Tsuji M.  2005.  Glycolipid-presentation to natural killer T cells differs in an organ-dependent fashion.  Proc Natl Acad Sci USA.  102: 1127-32. [view]
  17. Chen G, Schmieg J, Tsuji M, Franck RW.  2004.  Efficient Synthesis of alpha-C-Galactosyl Ceramide Immunostimulants: Use of Ethylene-Promoted Olefin Cross-Metathesis.  Org Lett  6: 4077- 80. [view]
  18. Bruna-Romero O, Rocha CD, Tsuji M, Gazzinelli RT.  2004.  Enhanced protective immunity against malaria by vaccination with a recombinant adenovirus encoding the circumsporozoite protein of Plasmodium lacking the GPI-anchoring motif.  Vaccine  22: 3575-84. [view]
  19. Yang G, Schmieg J, Tsuji M, Franck RW.  2004. The C-glycoside analogue of the immunostimulant alpha-galactosylceramide (KRN7000): synthesis and striking enhancement of activity.  Angew Chem Int Ed Engl 19: 3818-22. [view]
  20. Schmieg J, Yang G, Franck RW, Tsuji M.  2003.  Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand a-galactosylceramide.  J Exp Med   198: 1631-41. [view]
  21. Schmieg J, Gonzalez-Aseguinolaza G, Tsuji M.  2003.  The role of natural killer T cells and other T cell subsets against infection by liver stages of malaria parasites.  Microbes and Inf 5: 499-506.  Review. [view]
  22. Bruna-Romero O, Schmieg J, Del Val M, Buschle M, Tsuji M. 2003.  The dendritic cell-specific chemokine DC-CK1 enhances protective cell-mediated immunity to murine malaria.  J Immunol  170: 3195-203. [view]
  23. Tsuji M, Zavala F.  2003.  T cells as mediators of protective immunity against malaria liver stages.  Trends in Parasitol  19: 88-93.  Review. [view]
  24. Gonzalez-Aseguinolaza G, Schmieg J, Berraondo P, Ochoa L, Tsuji M.  2002.  The involvement of CD1d-restricted NKT cells in infectious processes.  Revision  21: 145-55.  Review. 
  25. Tsuji M.  2002.  Assessing antigen-specific CD4+ and CD8+ T cell responses in mice after immunization with recombinant viruses.  In: Malaria Methods and Protocols.  Methods in Molecular Medicine.  New Jersey: Humana Press Inc.  Vol. 72: 361-7. [view]
  26. Gonzalez-Aseguinolaza G, Van Kear L, Bergmann CC, Wilson JM, Schmieg J, Kronenberg M, Nakayama T, Taniguchi M, Koezuka Y, Tsuji M.  2002.  Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines.  J Exp Med  195:  617-24. [view]
  27. Tsuji M, Zavala F.  2001.  Peptide-based subunit vaccines against pre-erythrocytic stages of malaria parasites.  Mol Immunol   38; 433-42.  Review. [view]
  28. Bruna-Romero O, Gonzalez-Aseguinolaza G, Hafalla JC, Tsuji M. Nussenzweig RS.  2001. Complete, long-lasting protection against malaria of mice primed and boosted with two distinct viral vectors expressing the same plasmodial antigen.  Proc Natl Acad Sci U S A.  98: 11491-6. [view]
  29. Bruna-Romero O. Hafalla JCR, Gonzalez-Aseguinolaza G, Sano G-I, Tsuji M, Zavala F.  2001.  Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR.  Int J Parasitol    31: 1499-502. [view]
  30. Tsuji M, Rodrigues EG, Nussenzweig RS.  2001.  Progress towards a malaria vaccine: Efficient induction of anti-malaria immunity.  Biol Chemistry   382: 553-70.  Review. [view]
  31. Rodrigues EG, Tsuji M.  2000.  Malaria Vaccine Development: Various immunization regimens for efficient induction of protective anti-malaria immunity. Science and Culture  52: 288-304.  Review.
  32. Fernandez JA, Rodrigues EG, Tsuji M.  2000.  Multifactorial protective mechanisms to limit viral replication in the lung of mice during primary murine cytomegalovirus infection.  Viral Immunol   13: 287-95. [view]
  33. Pasquetto V, Guidotti LG, Kakimi K, Tsuji M, Chisari FV.  2000.  Host-virus interactions during malaria infection in hepatitis B virus transgenic mice.  J Exp Med  192: 529-36. [view]
  34. Cady CT, Lahn M, Vollmer M, Tsuji M, Seong JS, Reardon CL, O’Brien RL, Born W.  2000.  Innate response of murine gd T cells to the synthetic polypeptide, poly Glu50Tyr50.  J Immunol   165: 1790-8. [view]
  35. Gonzalez-Aseguinolaza G, de Oliveira C, Tomaska M, Hong S, Bruna-Romero O, Nakayama T, Taniguchi M, Bendelac A, Van Kaer L, Koezuka Y, Tsuji, M.  2000.  a-GalCer-activated Va14 natural killer T cells mediate protection against murine malaria. Proc Natl Acad Sci USA.   97: 8461-6. [view]
  36. Nagaoka H, Gonzalez-Aseguinolaza G, Tsuji M, Nussenzweig M.  2000.  Immunization and infection change the number of RAG expressing B cells in the periphery by altering immature lymphocyte production.  J Exp Med   191: 2113-20. [view]
  37. Molano A, Chiu Y-H, Nosseir S, Bendelac A, Tsuji M.  2000.  Cutting Edge: The IgG response to the circumsporozoite protein is MHC class II-dependent and CD1d-independent: Exploring the role of GPIs in NKT cell activation and antimalarial responses.  J Immunol   164: 5005-9. [view]
  38. McKenna KC, Tsuji M, Sarzotti M, Sacci JBJr, Witney AA, Azad A.  2000.  gamma/delta T cells are a component of early immunity against preerythrocytic malaria parasites.  Inf Immun   68: 2224-30. [view]
  39. Rodrigues EG, Claassen J, Lee S, Wilson JM, Nussenzweig RS, Tsuji M.  2000.  Interferon-gamma Independent CD8+ T cell-mediated protective anti-malaria immunity induced by recombinant adenovirus. Parasite Immunol   22: 157-60. [view]
  40. de Oliveira CI, Wunderlich G, Levitus G, Soares IS. Rodrigues MM, Tsuji M, del Portillo HA.  1999. Immunogenic properties of the merozoite surface proteint 1 gene of Plasmodium vivax.  Vaccine  17: 2959-68. [view]
  41. Yoneto T, Yoshimoto T, Wang C-R, Takahama Y, Tsuji M, Waki S. Nariuchi H.  1999.  Gamma interferon production is critical for protective immunity to infection with blood-stage Plasmodium berghei XAT but neither NO production nor NK cell activation is critical. f Immun   67: 2349-56. [view]
  42. Fernandez JA, Zavala F, Tsuji M.  1999.  Phenotypic and functional characterization of CD8+ T cell clones specific for a mouse cytomegalovirus epitope.  Virology  155: 40-9. [view]
  43. Rodrigues EG, Zavala F, Nussenzweig RS, Wilson JM, Tsuji M.  1998.  Efficient induction of protective anti-malaria immunity by recombinant adenovirus.  Vaccine  16: 1812-7. [view]
  44. Born W, Tsuji M, Cady C, Lahn M, Mukasa A, Reardon C, O’Brien R.  1998.  Establishment of murine T cell lines and clones, hybridomas and transfectomas.  In: Kaufman S, Kabelitz, D. eds.  Methods in Microbiology.  New York, Academic Press, 25: 205-35.
  45. Tsuji M, Bergmann CC, Takita-Sonoda Y, Murata K, Rodrigues EG, Nussenzweig RS, Zavala F.  1998.  Recombinant Sindbis viruses expressing a cytotoxic T lymphocyte epitope of a malaria parasite or of an influenza virus elicit protection against the corresponding pathogen in mice.  J Virol    72: 6907-10. [view]
  46. Miyahira Y, Garcia-Sastre A, Rodriguez JR, Rodriguez D, Murata K, Tsuji M, Esteban M, Palese P, Zavala F  Nussenzweig, R.S.  1998.  Recombinant viruses expressing a human malaria antigen elicited protective cellular and humoral responses in mice.  Proc Natl Acad Sci USA   95: 3954-9. [view]
  47. Rodrigues EG, Zavala F, Eichinger D, Wilson JM, Tsuji M.  1997.  Single immunizing dose of recombinant adenovirus efficiently induces CD8+ T cell-mediated protective immunity against malaria.  J Immunol   158: 1268-74. [view]
  48. Murata K, Garcia-Sastre A, Tsuji M, Rodrigues M, Rodriguez D, Rodriguez JR, Nussenzweig, RS, Palese P, Esteban M, Zavala F.  1996.  Characterization of in vivo primary and secondary CD8+ T cell responses induced by recombinant influenza and vaccinia viruses.  Cell Immunol   173: 96-107. [view]
  49. Takita-Sonoda Y, Tsuji M, Kamboj K, Nussenzweig RS, Clavijo P, Zavala F.  1996.  Plasmodium yoelii: Peptide immunization induces protective CD4+ T cells against a previously unrecognized cryptic epitope of the circumsporozoite protein.  Exp Parasitol   84: 223-30. [view]
  50. Briones M, Tsuji M, Nussenzweig V.  1996.  The large difference in infectivity for mice of Plasmodium berghei and Plasmodium yoelii sporozoites cannot be correlated with their ability to enter into hepatocytes.  Mol Bio Parasitol   77: 7-17. [view]
  51. Tsuji M, Eyster C, O’Brien R, Born WK, Bapna M, Reichel M, Nussenzweig RS, Zavala F.  1996. Phenotypic and functional properties of murine g/d T cell clones derived from malaria immunized, ab T cell-deficient mice.  Int Immunol   8: 359-66. [view]
  52. Reardon CL, Heyborne K, Tsuji M, Zavala, F, Tigelaar, RE, O’Brien RL Born WK.  1995.  Murine epidermal Vg5/Vd1- TCR+ T cells respond to B cell lines and lipopolysaccharides.  J Invest Dermatology  105: 58-61. [view]
  53. Tsuji M, Miyahira Y, Nussenzweig RS, Aguet M and Zavala F.  1995.  Development of anti-malaria immunity in mice lacking interferon-g receptor.  J Immunol  154: 5338-44. [view]
  54. Tsuji M, Mattei D, Nussenzweig RS, Eichinger D,  Zavala F.  1994.  Demonstration of heat-shock protein 70 in the sporozoite stage of malaria parasites.  Parasitol Res  80: 16-21. [view]
  55. Tsuji M, Mombaerts P, Lefrancois L, Nussenzweig RS, Zavala F Tonegawa S.  1994.  g/d Tcells contribute to immunity against the liver stages of malaria in a/b T cell-deficient mice.  Proc Natl Acad Sci USA  91: 345-9. [view]
  56. Feng Z., Hoffman RN, Nussenzweig RS, Tsuji M, Fujioka H, Aikawa M, Lensen THW, Ponnudurai T, Pologe LG.  1993.  Pfs 2400 can mediate antibody-dependent malaria transmission inhibition and may be the Pasmodium falciparum 11.1 gene product.  J Exp Med  177: 273-81. [view]
  57. Tsuji M, Corradin G, Zavala F.  1992.  Monoclonal antibodies recognize a processing dependent epitope present in the mature CS protein of various plasmodial species.  Parasite Immunol  14: 457-69. [view]
  58. Tsuji M, Romero P, Nussenzweig RS, Zavala F. 1990.  CD4+ cytolytic T cell clone confers protection against murine malaria.  J Exp Med  172:1353-7. [view]
  59. Tada T, Sano K, Tsuji M, Fujisawa I, Asano Y. 1987.  Autoimmunity and immune circuit.  In:  Wigzell H, Kyogoku M. eds. New Horizons in Animal Models for Autoimmune Disease.  New York: Academic Press, 341-7.
  60. Tsuji M, Yagi J, Abe R, Asano Y, Tada T.  1987.  Shared idiotopes between anti-class II monoclonal antibodies and major histocompatibility complex restriction site of T cells.  Eur J Immunol  117: 675-81. [view]
  61. Tada T, Fujisawa I, Sano K, Tsuji M, Yagi J, Asano Y, Uracz W.  1986.  The immune circuit: Somatic generation of epitopes involved in the mutual recognition by different subsets of T cells.  In: Reichlin M, Capra JD, eds. Idiotypes. New York: Academic Press, 249-61.
  62. Tada T, Asano Y, Fujisawa I, Yagi J, Sano K, Tsuji M, Nakayama T.  1986.  Adaptive construction of the immune circuit.  Prog Immunol VI  427-37.
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