Research Labs: Mark Muesing, Ph.D.
Selected Publications

Scientific Overview Non-Scientific Summary Mark Muesing, Ph.D.    CV    Personnel    Publications Return to Research Programs

• Muesing M, Tamm J, Shepard M, and B Polisky. (1981) A single base-pair alteration is responsible for the DNA overproduction phenotype of a plasmid copy-number mutant. Cell 24: 235-242. [view]
  
• Cesareni G, Muesing M, and B Polisky. (1982) Control of ColE1 DNA replication: The rop gene product negatively affects transcription from the replication primer promoter. Proc. Natl. Acad. Sci. (USA) 79: 6313-6317. [view]
  
• Wong E, Muesing M, and B Polisky. (1982) Temperature-sensitive copy number mutants are located in an untranslated region of the plasmid genome. Proc. Natl. Acad. Sci. (USA) 79: 3570-3574.[view]
  
• Muesing MA, Smith DH, Cabridilla CD, Benton CV, Lasky LA, and DJ Capon. (1985) Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus. Nature 313: 450-458. [view]
  
• Muesing MA, Smith DH, and DJ Capon. (1987) Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein. Cell 48: 691-701. [view]
  
• Emerman M, Guyader M, Baltimore D, Montagnier L, and MA Muesing. (1987) The specificity of the human immunodeficiency virus type 2 transactivator is different from that of human immunodeficiency virus type 1. EMBO 6: 3755-3760. [view]
  
• Wiskerchen M, and MA Muesing. (1995) Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells. J. Virol. 69: 376-386. [view]
  
• Wiskerchen M, and MA Muesing. (1995) Identification and characterization of a temperature-sensitive mutant of human immunodeficiency virus type 1 by alanine scanning mutagenesis of the integrase gene. J. Virol. 69: 597-601. [view]
  
• Jungheim LN, Shepherd TA, Baxter AJ, Burgess J, Hatch SD, Lubbehusen P, Wiskerchen M and MA Muesing. (1996) Potent HIV-1 protease inhibitors which utilize noncoded D-amino acids as P2/P3 ligands. J. Med. Chem. 39: 96-108. [view]
  
• Fletcher TM, Soares MA, McPherson S, Hui H, Wiskerchen M, Muesing MA, Shaw GM, Leavitt AD, Boeke JD, and Hahn BH. (1997) Complementation of integrase function in HIV-1 virions. EMBO 16: 5123-5238. [view]
  
• Kaldor et al. (1997) Viracept (Nelfinivir mesylate, AG1343): A potent, orally bioavailable inhibitor of HIV-1 protease. J. Med. Chem. 40: 3979-3985. [view]
  
• Stashke KA, Hatch SD, Tang JC, Hornback WJ, Colacino JM, and MA Muesing (1998) Inhibition of Influenza Virus Hemagglutinin-Mediated Fusion by a Compound Related to Podocarpic Acid. Virology 248: 264-274. [view]
  
• Gordon C, Muesing MA, Proudfoot AEI, Power CA, Moore JP and A Trokla (1999) Enhancement of Human Immunodeficiency Virus type 1 infection by the CC-chemokine RANTES is independent of the mechanism of virus-cell fusion. J. Virol. 73: 684-694. [view]
  
• Mulder L. and MA Muesing. (2000) The Stability of HIV-1 Integrase is Regulated by the N-end Rule. JBC 275: 29749-53. [view]
  
• Mulder LC, Chakrabarti LA, Muesing MA. (2002) Interaction of HIV-1 Integrase with DNA Repair Protein hRad18. J Biol Chem. 26;277(30):27489-93 [view]
  
• Cowan S, Hatziioannou T, Cunningham T, Muesing MA, Gottlinger HG and PD Bieniasz (2002) Cellular inhibitors with FV-1-like activity restrict human and siamian immunodeficiency virus tropism. Proc. Natl. Acad. Sci. USA. 99: 11914-9. [view]
  
• Fischer M, Trkola A, Joos B, Hafner R, Joller H, Muesing MA, Kaufman DR, Berli E, Hirschel B, Weber R. and H F Gunthard (2003) Shifts in cell associated HIV-1 RNA but not in episomal HIV-1 DNA correlate with new cycles of HIV-1 infection in vivo, Antiviral Therapy, 8:97-104. [view]
  
• Tasaki T, Mulder LCF, Iwamatsu A, Lee MJ, Varshavsky A, Muesing M, and YT Kwon (2005) N-terminus-dependent proteolysis by the UBR box proteins. Mol. Cell Biol. 25: 7120-36. [view]
  
• Lloyd AG, Tateishi S, Bieniasz PD, Muesing MA, Yamaizumi M and LCF Mulder (2006) Effect of DNA repair protein Rad18 on viral infection. PLoS Pathogens, 2: 368-73. [view]
  
• Low A and MA Muesing(2006) Understanding and inhibiting integrase in the treatment of HIV disease. PRN Notebook 11: 6-11. [view]
  
• Lloyd AG, Ng YS, Muesing MA Simon V and LCF Mulder (2007) Characterization of HIV-1 integrase N-terminal mutant viruses. Virology, 360:129-35. [view]
  
• Topper MB, Luo Y, Zhadina M, Mohammed K, Smith L and MA Muesing (2007) Post-translational acetylation of the carboxyl-terminal domain of integrase is dispensible for viral replication. J Virol, 81:3012-7. [view]
  
• Berthoux L, Sebastian S, Muesing MA, Luban J (2007) The role of lysine 186 in HIV-1 integrase multimerization. Virology; 364:227-36. [view]